Linezolid (Generic Zyvox)

What is Linezolid (Zyvox Generic)?

• Linezolid in Zyvox Generic is an Antibiotic drug, belongs to completely new class of antibiotics called as Oxazolidinone. Zyvox (Generic Linezolid) is an Oxazolidinone antibiotic that fights bacteria in the body.
• It works by interfering with the protein (require by bacteria to increase in numbers and multiply further) synthesis (proteins needed by bacteria to grow) in bacteria, this inhibits the ability of the bacteria to grow and replicate and therefore stops the spread of bacterial infection, hence stopping the bacterial growth in the body.
• Zyvox (Linezolid) generic medication is used to treat different types of very serious bacterial infections, such as pneumonia, skin infections, and infections that are resistant to other antibiotics such as MRSA (Methicillin-resistant Staphylococcus aureus (MRSA) , VISA/ VRSA (Vancomycin-Intermediate/Resistant Staphylococcus aureus), Glycopeptide-Intermediate Staphylococcus aureus (GISA) and other serious hospital acquired infections.
• Zyvox (Linezolid) generic medication may also be used for purposes other than those listed in this medication guide.

Generic name: Linezolid

Available as: 600 mg Tablet Form

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• Linezolid (Generic Zyvox) is an Oxazolidinone antibiotic that fights bacteria in the body.
• This medication is used for treating very serious bacterial infections, such as pneumonia, skin infections, and infections that are resistant to other antibiotics such as
• MRSA (Methicillin-resistant Staphylococcus aureus (MRSA) ,
• VISA/ VRSA (Vancomycin-Intermediate/Resistant Staphylococcus aureus),
• Glycopeptide-Intermediate Staphylococcus aureus (GISA) and other serious hospital acquired infections.
• It works by interfering with the production of proteins needed by bacteria to grow.

• Zyvox (Linezolid) generic is a bacteriostatic (inhibits the bacterial growth in body) belongs to Oxazolidinone class of antibiotics, it inhibits ribosomal protein synthesis in the bacteria and thereby killing the bacteria completely.
• It is active against gram-positive bacteria including vancomycin-resistant enterococci and MRSA, VISA/ VRSA (Vancomycin-Intermediate/Resistant Staphylococcus aureus), Glycopeptide-Intermediate Staphylococcus aureus (GISA) and other serious hospital acquired infections.

• Follow the directions for using this medicine provided by your doctor.
• This medicine may be taken on an empty stomach or with food.
• Antibiotics work best when the amount of medicine in your body is kept at a constant level.
• Therefore, take this drug at evenly spaced intervals.
• Continue to take this medication until the full-prescribed amount is finished even if symptoms disappear after a few days.
• Stopping linezolid medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.
• Inform your doctor if your condition does not improve in 10 days.

• If you miss a dose of linezolid, use it as soon as you remember.
• If it is near the time of the next linezolid dosage, skip the missed dose of linezolid dosage and resume your usual dosing schedule.
• Do not double the dose of linezolid dosage.

• This medicine may cause dizziness and so may affect your ability to drive or operate machinery safely.
• Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.
• While taking this antibiotic you should avoid consuming large amounts of foods and drink that contain high levels of the amino acid tyramine, as this can cause a dangerous rise in blood pressure.
• Tyramine-rich foods include matured cheeses, yeast extracts (eg Oxo, Bovril, Marmite), undistilled alcoholic drinks (particularly draught beer and wine) and fermented soya bean products (eg soy sauce).
• Ask your pharmacist for more information. If you develop a throbbing headache after eating or drinking, tell your doctor or pharmacist.
• This medicine may cause a decrease in the normal amount of blood cells in the blood. Decreased red blood cells or haemoglobin can result in anaemia, decreased white blood cells can increase susceptibility to infections and decreased numbers of cells called platelets can cause problems with blood clotting.
• For this reason, you will need to have a weekly blood test to monitor the composition of your blood while taking this antibiotic.
• The following groups of people may need to be more closely monitored: people who already have anaemia, low white blood cell counts or low platelet counts, people taking other medicines that can reduce blood counts, levels of platelets or haemoglobin, people with impaired kidney function and people who receive more than 10-14 days of treatment with this medicine.
• Antibiotics can sometimes cause inflammation of the bowel (colitis). For this reason, if you get diarrhoea either during or after taking this medicine, particularly if it becomes severe or persistent or contains blood or mucus, you should consult your doctor immediately.
• You should consult your doctor as soon as possible if you experience any changes in your vision, for example, blurred vision, tunnel vision, difficulty seeing fine detail, or changes in your colour vision, while taking this antibiotic.
• Unless your doctor tells you otherwise, it is important that you finish the prescribed course of this antibiotic medicine, even if you feel better or it seems the infection has cleared up. Stopping the course early increases the chance that the infection will come back and that the bacteria will grow resistant to the antibiotic.
• The manufacturer states that this antibiotic should not normally be used for longer than 28 days, as they have not studied its safety and effectiveness when used for longer than this. If for any reason your doctor has asked you to keep taking this antibiotic for longer than 28 days, your eyesight should be regularly monitored.
• Use Zyvox (Linezolid) generic drug with caution in
• Decreased kidney function
• People having haemodialysis for kidney failure
• Severely decreased liver function
• Uncontrolled high blood pressure (hypertension)
• Tumour of the adrenal gland (phaeochromocytoma)
• Tumour in the intestine called a carcinoid tumour
• Thyrotoxicosis
• Bipolar affective disorder (manic depression)
• Mental disorder with symptoms of schizophrenia and mood disorder (schizoaffective disorder)
• Acute states of confusion
• Anaemia
• People with low numbers of white blood cells in their blood
• People with low numbers of cells called platelets in their blood (thrombocytopenia)

• People who have taken a monoamine-oxidase inhibitor medicine in the last 14 days (see below for more information)
• Breastfeeding.
• Zyvox oral solution contains aspartame, which is a source of phenylalanine, and so is not suitable for people with phenylketonuria. Zyvox oral solution also contains sucrose and so is not suitable for people with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency. Zyvox tablets or infusion should be used for people with any of these disorders.
• This antibiotic is not recommended for children and adolescents under 18 years of age, as there is no information regarding its safety and efficacy in this age group.
• This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
• If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
• Linezolid (Generic Zyvox) drug in Pregnancy and Breastfeeding
• Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
• The safety of this medicine for use during pregnancy has not been established. It is not recommended for use in pregnancy unless considered essential by your doctor. Seek medical advice from your doctor.
• This medicine may pass into breast milk. Mothers who need to take this medicine should not breastfeed their infants during treatment. Discuss with your doctor.

• Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
• Headache
• Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
• Yeast infection of the moist areas of the body, especially the vagina and mouth (candidiasis)
• Metallic taste
• Decreased numbers of red blood cells, haemoglobin, white blood cells or platelets in the blood
• Alteration in results of liver function tests
• Fatigue
• Fever
• Dizziness
• Pins and needles sensations (paraesthesia) or numbness
• Difficulty in sleeping (insomnia)
• Blurred vision
• Sensation of ringing or buzzing in the ears (tinnitus)
• High blood pressure (hypertension)
• Rash or itching
• Inflammation of the pancreas (pancreatitis)
• Kidney failure
• Sudden loss of brain function with full recovery within 24 hours (transient ischaemic attack)
• The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
• For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

• It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.
• Similarly, ask your doctor or pharmacist before taking any new medicines while taking this one, so they can check that the combination is safe.

• the antidepressants phenelzine, isocarboxacid or tranylcypromine
• moclobemide for depression
• selegiline or rasagiline for Parkinson's disease.
• Linezolid should not be taken by people taking any of the following medicines unless the individual is under close medical observation and their blood pressure is monitored:
• SSRI antidepressants, eg fluoxetine, paroxetine
• tricyclic antidepressants, eg amitriptyline, imipramine
• triptans for migraine, eg sumatriptan, almotriptan, rizatriptan
• decongestants, eg pseudoephedrine, phenylpropanolamine, ephedrine, phenylephrine (these are often found in cold and flu remedies)
• medicines that open the airways, eg salbutamol, salmeterol, terbutaline
• amphetamines
• methylphenidate
• adrenaline
• noradrenaline
• pethidine
• buspirone
• dopamine
• dobutamine.
• Other medicines containing the same active ingredient

• Your pharmacist has information about Linezolid (Generic Zyvox) written for health professionals that you may read.
• This information is not a substitute for individual medical attention. See your health care professional for medical advice and treatment. Read the product information leaflet provided with the product before using it.