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Levaquin (Levofloxacin) is a member of the quinolone family of antibiotics. Levofloxacin antibiotics known as fluoroquinolones is used for the treatment of bacterial infections, which cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections and infections of the prostate.
Levaquin cures a variety of bacterial infections, including several types of sinus infection and pneumonia. It is also prescribed for flare-ups of chronic bronchitis, acute kidney infections, certain urinary or chronic prostate infections, and skin infections. Levofloxacin is available under the brans names Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox all contains active drug Levofloxacin.
Generic Name: Levofloxacin
Available As: 250mg, 500mg, 750mg tablets form
Is Generic Levofloxacin is as effective as the brand name drug Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox?
Yes, since the generic drugs are manufactured by using the same process, same chemical and under tough and close examination and further inspection by US FDA as the branded drugs, the difference between branded and generic drugs Click here for more information
Do NOT use Levofloxacin (Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox) if:
- you are allergic to any ingredient in Levofloxacin or to any other quinolone antibiotic (eg, ciprofloxacin)
- you have a certain type of irregular heartbeat (QT prolongation, long QT syndrome) or low blood potassium levels
- you are taking cisapride or certain antiarrhythmics (eg, amiodarone, procainamide, quinidine, sotalol)
- Contact your doctor or health care provider right away if any of these apply to you.
Levofloxacin Generic (Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox) dosages?
- Adults: Dose is determined on the basis of severity of the infection, type of infecting organism, age, weight and renal function of the patient.
- Sinusitis, Bronchitis, Pneumonia, Skin and soft tissue infections: 500 mg daily for 1 - 2 week
- Urinary tract infection: 250 mg / day for 10 days
- Traveler`s diarrhoea: 500 mg / day along with Loperamide
- Urethritis: 500 mg orally once daily for 7 days
Levofloxacin drug Mechanism of Action?
- Levofloxacin is a broad spectrum antibacterial agent. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.
- DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix.
- Levofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired.
- This will inhibits transcription of DNA in to RNA and subsequent protein synthesis and death of bacteria.
Most important fact about Levofloxacin (Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox)
Levofloxacin in Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox has been known to cause dangerous allergic reactions as soon as you take the first dose. Stop taking the drug and call your doctor immediately if you develop any of the following warning signs:
- Skin rash, hives, or any other skin reaction
- Rapid heartbeat
- Difficulty swallowing or breathing
- Swelling of the face, lips, tongue, or throat
- Special information if you are pregnant or breastfeeding
- The possibility that Levaquin might harm a developing baby has not been ruled out. It should be used during pregnancy only if the potential benefit outweighs the possible risk.
- If you are pregnant or plan to become pregnant, inform your doctor immediately. Levaquin is likely to appear in breast milk and could harm a nursing infant. If the drug is essential to your health, your doctor may advise you to stop nursing until your treatment is finished.
- Do not take fluoroquinolones if you are pregnant.
- Do not give fluoroquinolones to infants, children, or teenagers unless otherwise directed by your doctor.
- These medicines have been shown to cause bone development problems in young animals.
- Fluoroquinolones should be used only to treat bacterial infections and not viral infections like the common cold.
- To help clear up your infection completely, keep taking your medicine for the full time of treatment , even if you begin to feel better after a few days.
- If you stop taking this medicine too soon, your symptoms may return.
Levofloxacin indications and usage?
Levofloxacin is indicated for the treatment of acute bacterial exacerbation of chronic bronchitis, acute bacterial sinusitis, acute pyelonephritis, anthrax (inhalational, postexposure), chronic bacterial prostatitis, community-acquired pneumonia, complicated and uncomplicated skin and skin structure infections, complicated and uncomplicated UTI, and nosocomial pneumonia caused by susceptible strains of specific microorganisms.
Levofloxacin Contraindications?
Do not use Levofloxacin (Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox) if you are
Hypersensitivity to fluoroquinolones, quinolone antibiotics, or any product component.
Before using Levofloxacin (Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox) medication treatment?
Some medical conditions may interact with Levofloxacin. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you or a family member have a history of fast, slow, or irregular heartbeat (eg, QT prolongation); chest pain; angina; or heart attack
- if you have a history of other heart problems (eg, heart failure, enlarged heart), diabetes, liver problems, kidney problems, tendon problems (eg, inflammation), or Alzheimer disease
- if you have narrowed or hardened blood vessels in the brain, increased pressure in the brain, nervous system problems, or a history of seizures (eg, epilepsy)
- if you sunburn easily or you will be in the sun for a prolonged period of time
Some medicines may interact with Levofloxacin. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Antiarrhythmics (eg, amiodarone, procainamide, quinidine, sotalol), arsenic, astemizole, cisapride, dofetilide, droperidol, haloperidol, imidazoles (eg, ketoconazole), macrolides (eg, erythromycin), methadone, paliperidone, phenothiazines (eg, chlorpromazine), pimozide, ranolazine, serotonin receptor antagonists (eg, dolasetron), telithromycin, terfenadine, or ziprasidone because the risk of serious heart problems, including irregular heartbeat, may be increased
- Insulin or oral diabetes medicines (eg, glyburide) because the risk of high or low blood sugar may be increased
- Corticosteroids (eg, prednisone) because the risk of tendon problems may be increased
- Anticoagulants (eg, warfarin) because the risk of bleeding may be increased
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) or theophylline because the risk of serious side effects, including seizures, may be increased
- Serotonin norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine) because the risk of their side effects may be increased by Levofloxacin
- This may not be a complete list of all interactions that may occur. Ask your health care provider if Levofloxacin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Levofloxacin important safety information:
- Levofloxacin may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Levofloxacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
- Levofloxacin only works against bacteria; it does not treat viral infections (eg, the common cold).
- Be sure to use Levofloxacin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Long-term or repeated use of Levofloxacin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Tendon problems have been reported with Levofloxacin . Some of these problems have been severe. Contact your doctor right away if you develop pain or swelling of a joint or tendon.
- Levofloxacin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Levofloxacin . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- If you are scheduled to receive a typhoid vaccine while you are taking Levofloxacin , talk with your doctor. Levofloxacin may decrease the effectiveness of the vaccine.
- Diabetes patients - Levofloxacin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Levofloxacin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Levofloxacin .
- Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Levofloxacin . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Levofloxacin with caution in the ELDERLY; they may be more sensitive to its effects (eg, tendon problems), especially if they take corticosteroids (eg, prednisone). They may also be more sensitive to other effects (eg, irregular heartbeat, liver problems).
- Levofloxacin should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed. Children may also be more sensitive to joint and tendon problems.
Is is safe to use Levofloxacin in Pregnancy and Breast-feeding?
- If you become pregnant, contact your doctor.
- You will need to discuss the benefits and risks of using Levofloxacin while you are pregnant.
- Levofloxacin is found in breast milk.
- Do not breast-feed while taking Levofloxacin medicine.
What happens if I miss a dose of Levofloxacin?
- Take the missed dose as soon as you remember. If you are more than 2 hours late in taking your medicine, skip the missed dose and take the medicine at the next regularly scheduled time.
- Do not take extra medicine to make up the missed dose.
What happens if I overdose Levofloxacin?
Seek emergency medical attention if you think you have taken too much of this medicine. Overdose symptoms may include loss of balance or coordination, drooping eyelids, weakness, decreased activity, trouble breathing, sweating, tremors, or seizure (convulsions).
Levofloxacin side effects?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- diarrhea that is watery or bloody;
- seizure (convulsions);
- confusion, hallucinations, unusual thoughts or behavior;
- dizziness, fainting, fast or pounding heartbeat;
- sudden pain or swelling near your joints (especially in your arm or ankle);
- easy bruising or bleeding;
- urinating less than usual or not at all;
- numbness, burning, pain, or tingly feeling in your hands or feet;
- pale or yellowed skin, dark colored urine, fever, weakness;
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
- jaundice (yellowing of the skin or eyes).
Less serious side effects with levofloxacin may include:
- nausea, vomiting, stomach pain, constipation;
- feeling restless or anxious;
- headache, dizziness;
- muscle pain;
- sleep problems (insomnia), or nightmares;
- vaginal itching or discharge; or
- mild skin itching.
- This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
What other possible drugs can affect levofloxacin?
- Many drugs can interact with levofloxacin. Below is just a partial list. Tell your doctor if you are using:
- a blood thinner such as warfarin (Coumadin);
- cyclosporine (Neoral, Sandimmune, Gengraf);
- insulin or diabetes medication you take by mouth;
- theophylline (Theo-Dur, Theolair, Slo-Phyllin, Slo-Bid, Elixophyllin);
- aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), indomethacin, naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others; or
- heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), ibutilide (Corvert), procainamide (Procan, Pronestyl), quinidine (Quinidex, Quin-Release Quin-G), or sotalol (Betapace).
- This list is not complete and there may be other drugs that can interact with levofloxacin.
- Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.
- Do not start taking a new medication without telling your doctor.
More information on levofloxacin generic Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox?
- If you have any questions about Levofloxacin, please talk with your doctor, pharmacist, or other health care provider.
- Levofloxacin is to be used only by the patient for whom it is prescribed.
- Do not share levofloxacin generic Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- This information is a summary only. It does not contain all information about Levofloxacin.
- If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Where can I get more information on levofloxacin generic Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox?
Your pharmacist can provide more information about levofloxacin generic Levaquin, Tavanic, Gatigol, Lebact, Terlev, Cravit and Levox.
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