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Posts Tagged ‘Generic Drugs’
Generic Viagra: Beat Impotence Perfectly
July 15th, 2010
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No More New Molecule For Cardiovascular Ailments as Pharmaceutical Firms Shift Focus
May 30th, 2009
admin Pharmaceutical Firms Shy away from Cardio Molecule Research Lipitor innovator Pfizer too has shifted focus from Cardiovascular Ailments to other Diseases.
Realpharmacyrx.com: A recent issue of British medical journal The Lancet found that heart diseases kill 3 million people in India annually, accounting for a third of the total deaths in the country. The World Health Organization (WHO) estimates that by 2010, us will have 60% of the world’s heart patients. Hard-hitting facts, these. What’s more alarming is that not much research is being done in UK for developing new molecules in the area of cardiology.
Recently, US pharma giant Pfizer, which focused on cardiovascular diseases (CVD) research, decided to stop the development of new drugs for this segment and shift focus to areas such as Cancer Pills, Diabetes Pills, pain management, Alzheimer’s disease and inflammation. Pfizer is the innovator of blockbuster CVD drugs like Lipitor generic Atorvastatin and Norvasc Generic Amlodipine. Several leading domestic players are actively engaged in research to develop new chemical entities (NCE) or new biological entities (NBE). An NCE is a chemical molecule discovered and developed by a pharma company, which can become a drug after undergoing clinical trials. On the other hand, an NBE is derived from plants or animals and could become a drug on completion of clinical trials.
Though Indian pharma companies have NCEs and NBEs in the pipeline, the focus seems to be more on segments such as cancer (oncology), diabetes, pain management, chronic obstructive pulmonary disease (COPD) than on heart ailments, which affect over 20 million Indians. Players such as Wockhardt and Dr Reddy’s Laboratories have 2 and 4 NCEs in the pipeline, respectively, but none in cardiology. Likewise, Piramal Life Sciences and Sun Pharmaceuticals Advanced Research Centre (SPARC) have 14 and 4 NCEs, respectively, but again none for heart ailments. “Research in cardiology has plateaued. There are hardly any molecules in cardiology at present.” Indian firms are more inclined towards conducting clinical trials and not developing new molecules. However, Glenmark Pharma has one NBE for CVD, of the 8 NCEs and 5 NBEs it is working on. This molecule is currently in the preclinical stage.
On the other hand, Lupin has some NCEs in the pipeline, and spends 10% of its R&D budget on the cardiovascular space, a spokesperson said. “Indian players are less focused on cardiology even though India is becoming a major hub for heart-related ailments. Though domestic companies have presence in the cardiovascular market, it is more in the area of process development and analytical research.”
He added that where innovations are concerned, cardiology is a neglected area. Though there seem to be no clear reasons behind the trend, cost and fear of failure could be a couple of causes, say experts. “About 70-80% of heart diseases are preventable with existing medicines. The failure rate of molecules in cardiology is very high and so, for players, it is a major risk.”
“Over 5,000-7,000 patients are needed for phase III trials of a cardiology drug as against 2,000-3,000 for other drugs,” for more information about Blood Pressure Pills, Cholesterol Pills, Diabetes Pills please visit www.realpharmacyrx.com
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May 30th, 2009
admin Low price quality generic drugs manufactured by Dr Reddy’s (DRL), Sun pharma, Ranbaxy wins 7 drugs for AOK bids Still in the running for 20 more Generic products
Realpharmacyrx: Dr Reddy’s Laboratories (DRL), the Hyderabad-based pharma major, has gained some ground in the German market by winning a contract to supply seven products to AOK, one of the largest insurers in Germany. DRL had bid for supplying 33 drugs of 64 sought by AOK. For four of the seven it has won, DRL has marketing exclusivity in five regions identified by AOK. For the remaining three, the company will share the market with other pharma players. However, AOK has so far awarded contracts for just 44 molecules of the 64 it seeks. DRL has bid for the remaining 20 molecules too.
A DRL spokesperson said, “We have bid for the other molecules, the results of which are yet to be announced. So, the seven products offered to us are part of the first tranche of bids approved by AOK.”
Company officials disclosed neither the details of the products that will be supplied to AOK, nor their revenue implications. “It’s too early for us to quantify the impact. We are also evaluating the manufacturing details of the products that we will supply to AOK,” the spokesperson said.
DRL has a manufacturing facility near Hyderabad, which it is believed to have readied for manufacturing products for its German arm Betapharm. The company had signed a manufacturing deal with German firm Salutas for Betapharm products but it fell through due to supply issues. DRL then decided to shift the production of Betapharm’s products to India. The move is expected to give it a cost advantage and improved margins. DRL refused to disclose the pricing details of the seven products “due to competitive reasons”.
Meanwhile, analysts feel the bidding might have been aggressive and the pricing of the products may cut into margins significantly. A December 3 report by research firm CLSA said, “The preliminary analysis of AOK tender results indicates decent wins for Dr Reddy’s. It is likely that the company has bid aggressively and won for products where it is cost-competitive. However, delays in tender are possible due to the litigation risks cited earlier by Stada.”
The molecules it has won contracts for, analysts said, would be “where it has reasonable presence like (Generic Prilosec omeprazole (Anti-Acidity (Heartburn) pills), Cholesterol Pills Generic Zocor simvastatin“. “Stada and Ratiopharm (two other pharma majors in the race for the tender) have lost substantially. Stada already mentioned in its recent release that it would litigate against the tender. This will result in further delays,” the report said.
A Citi report dated December 2 too pointed at aggressive pricing but did not make any impact analysis of such pricing. “We believe bidding would have been aggressive, driving significant discounts to current prices. One of DRL’s competitors, Ratiopharm, indicated that it has not received anycontracts and appears to hint at low pricing as a reason. We await further clarity from the management on the net impact (lower pricing, higher volumes in selected products, potentially lower volumes in products where it missed out) before adjusting our estimates,” the Citi report said. for more low price quality generic drugs anufactured by Dr Reddy’s (DRL), Sun pharma, Ranbaxy etc. click here http://www.realpharmacyrx.com/
Generic Drug Prices Falling in the U.S. – Realpharmacyrx Online Pharmacy Special Offers Buy generic Drugs at 15 % Discounted Prices
May 30th, 2009
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Realpharmacyrx said the price competition is particularly egregious for the medicine had a brand-name blockbusters – recent example is the osteoporosis drug Fosamax and Cholesterol fighter Zocor – which “may have as many as 20 generic manufacturers competing for share.” Between now and 2012, brand-name drugs to $ 139 billion in annual sales in the top eight world markets will face generic competition, Realpharmacyrx known. Medicines that include the world of top-selling medicine, Pfizer Inc. ’s Cholesterol drug Lipitor, which has sales of nearly $ 13 billion a year. However, after that, the continued decline in the number of large new brand-name drugs are approved means fewer new generics.
Generics generate $ 78 billion in revenue in 26 countries with the highest sales in the year ending in September, an increase of only 3.6 percent the year before, Revenue was climbing by double digits for several years and take 11.4 percent in 2007. The report of the U.S. generic sales dipped from $ 34 billion in 2007 to $ 33 billion in the year ending in September, when generic drugs accounted for almost 64 percent of all prescriptions filled.
Among other major markets, revenue from generic drugs also declined in the UK, driven by price pressure from its national health system, but increased by double digits in France, Italy, Japan and Spain the cheap generic drugs.
IMS expects “seismic change” in the global generics industry in the next decade, as price pressures led to smaller generic manufacturers that profit margins are squeezed now captured by powerful players. Meanwhile, more large companies are branching out to developing brand-name drugs, more brand-name company trying to compensate for slow growth are making their own generics, and common versions of biotech drugs – not allowed in this country – is expected to become more common, extending the common market for all the products.
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May 29th, 2009
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3. Doctor’s Review: Many online pharmacies provide prescriptions that are issued, the medical review of the patient’s medical information. Although it may be difficult or embarrassing to talk about certain conditions with a local doctor, it is always best to consult them before any new medication. A complete physical should be done once a year, more than 40 years of age.
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Most people dread having to make a mobile medical office expects a waiting room for hours, and then spending even more time to consult your doctor. Then there is a mobile pharmacy. This could be a long, drawn-making process only to get needed prescription drugs. However, the Internet presents a lot easier way to get many of the prescription drug ads that we need. All of these will take on the door, and ordered all the comfort, convenience and privacy of your own home. When it comes down to it, people are just a way to supplement the small amount of free time, they are in their busy lives.
Not All Online Pharmacies are the same:
Although it seems that there are a number of online pharmacies touting all sorts of prices and deals have been the case, buyers beware! There is a lot of legal and legitimate pharmacies, but you always want to make sure you know where you are ordering your drugs.
Many of these online pharmacies are illegal operations located abroad. Many of them abandon the FDA approved by the fake, potentially harmful versions of brand-name drugs they do not have permission to produce.
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Pfizer buy Wyeth for $ 60 billion makes annual sales of more than $ 70 billion – Realpharmacyrx
May 29th, 2009
admin Will Pfizer buy Wyeth for $ 60 billion if yes than the combination would create a drug maker with annual sales of more than $ 70 billion – Realpharmacyrx.com
Online Pharmacy Realpharmacyrx.com – Pfizer Inc, the World’s largest drug maker is in talks to buy Wyeth in an attempt to replace the revenues expected to lose to generic competition in three years, according to a person familiar with the discussions. Both companies are U.S. based.
The deal could be worth as much as $ 60 billion, the Wall Street Journal reported earlier.
A combination would create a drug maker with annual sales of more than $ 70 billion and best-selling medicines, including cholesterol pill Lipitor and Prevn vaccine against pneumonia.
Pfizer CEO Jeffrey Kindler, 52, is already a reorganization to accelerate drug development and plans to fire personnel recession threatens to crimp sales. By acquiring Wyeth, Pfizer earnings may fall as low as 10% instead of 23% when it loses patent protection in 2011 on its Heart and Cholesterol Pills (Lipitor, Zocor) Quality and brand equivalent Generics drugs instead of Brands, which accounts for one fourth of their income, “said Deutsche Bank analyst Barbara Ryan in a note to customers on Friday.
Lipitor, the world’s best-selling medicine, generated $ 12.7 billion in sales for Pfizer in 2007. “Wyeth is perhaps the most levy play assuming that it will at least some big pharma consolidation over the next one to three years,” says Tim Anderson, analyst at Sanford Bernstein & Co., in a note to clients on Thursday. “The relative lack of a patent can help cut the Smoth hearings for the companies that are not as fortunate.”
An agreement would be the largest pharmaceutical acquisition of at least five years and may signal consolidation in the pharmaceutical industry.
Multinationals Pharma MNCs stake Indian top drug manufacturers – Realpharmacyrx.com
May 29th, 2009
admin Multinationals Pharma MNCs raise stake in Indian top pharmaceuticals drug manufacturers
With the market expected to grow strongly, it makes sense to strengthen grip. It is purely coincidental that last week, Novartis and Mylan announced plans to significantly hike equity stakes in their Indian subsidiaries like like Daiichi Sankyo – Ranabxy. More generic drug makers are going for Indian market. Swiss firm Novartis presently holds a little less than 51% stake in its Indian arm, while Pittsburgh-headquartered Mylan is 71% in Matrix Labs, the Hyderabad-based company it acquired in 2006 for a total consideration of $ 736 million. Novartis said it wants to increase its stake up to 90%, which is a threshold limit before a company can be de-listed. The company reportedly maintained that it will not de-list from the exchanges. But what powers can wield shareholders with just 10% of control in the company?
Mylan, on the other hand, expressed its objective to de-list the Matrix through an offer of up to Rs 150 per share if the promoter shareholding goes beyond 90%. Novartis, through its discovery research capabilities, brings out new drugs into the global markets, while Mylan is the third-largest generic drugs company in the world. Both have different business characteristics, but the aim to have a firmer hold over their Indian operations is almost similar. For a branded drug company, a bigger presence will mean greater flexibility of operation in India, while a generic drug company will find it impossible to compete without an overhauled backend research and manufacturing capability here.
Novartis, like every other Innovator, is grappling with a measly growth rate in its largest markets, while Mylan is finding it tough to grow without getting its calculations right on the manufacture of generic drugs. Ironically, India was never a priority for any of these companies until a few years ago. For Novartis, branded drugs were cash cows with no threat of patent expires and India was a high-volume, low-margin market known to contribute less than a percent to its global turnover. Now, with most Analysts putting a growth of over 14% for India for the next ten years, Novartis has to do its best to establish a strong presence here. Controversies regarding Glivec’s patents notwithstanding, Novartis will need to grow its marketing network in India to bring its latest products and add to its investments.
For decades, Novartis has piggybacked its traditional brands such as Voveran and Calcium Sandoz, but going into the next few years, market dynamics will become very compelling. Highly price products will be introduced by multi-national drug rivals and traditional strongholds will be invaded and may even crumble. Novartis has little choice but to add more muscle to retain its leadership position in certain segments and grow into the newer therapies like erectile dysfunction (ED) generic viagra (sildenafil citrate jelly) and weight loss pills like Acomplia Generic, Slimona (Rimonabant 20mg), Xenical (Orlistat 120mg Diet pills).
Till a few years ago, Mylan too had everything right before Indian drug companies started pounding their low-price drugs into the U.S. and upset many a large company through aggressive distribution of mass products. Mylan had become increasingly vulnerable to value erosion before it set its basics right. It decided to pick up a large majority stake in Matrix for a princely valuation of Rs 306 per share.
Mylan CEO and vice chairman Robert Coury then said in the press release, “Purchasing the remaining interest in the Matrix and delisting it from the exchanges will provide Mylan an opportunity for enhanced flexibility and efficiencies in managing our global technical and commercial operations platform.” Coury added, “The move represents another step toward achieving our goal of becoming the most efficient global generics and specialty pharmaceutical company in the industry. The transaction would also provide the Matrix’s public shareholders with an attractive near-term liquidity opportunity.” Mylan has a multitude of reasons to buy into the Matrix. Matrix was expected to provide it a significant presence in important emerging markets like India, Africa and China. Mylan had also announced it will grow into Europe through the Matrix’s Belgium unit Docpharma. By combining the Matrix’s capabilities in active pharmaceutical ingredient manufacturing and drug development business, Mylan said, it will have access to key products with higher barriers to entry and long-term growth opportunities as well as provide significant cost savings and enable first-in-trade — out product life cycles. The signals are getting increasingly clear. Sooner or later, more multinationals drug manufacturers will come into India through deals like Daiichi Sankyo – Ranabxy. The others will intend to the list and more generic drug makers may go for a stronger management control in the Indian market.
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May 23rd, 2009
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