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A 2007 study examining the risk of natural anomalies in children of pregnant women using statins suggest the ill effects of drugs may be limited to fat-soluble or “lipophilic” statins only.

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Generics generate $ 78 billion in revenue in 26 countries with the highest sales in the year ending in September, an increase of only 3.6 percent the year before, Revenue was climbing by double digits for several years and take 11.4 percent in 2007.
The report of the U.S. generic sales dipped from $ 34 billion in 2007 to $ 33 billion in the year ending in September, when generic drugs accounted for almost 64 percent of all prescriptions filled.

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Realpharmacyrx: Dr Reddy’s Laboratories (DRL), the Hyderabad-based pharma major, has gained some ground in the German market by winning a contract to supply seven products to AOK, one of the largest insurers in Germany.

DRL had bid for supplying 33 drugs of 64 sought by AOK. For four of the seven it has won, DRL has marketing exclusivity in five regions identified by AOK. For the remaining three, the company will share the market with other pharma players.

However, AOK has so far awarded contracts for just 44 molecules of the 64 it seeks. DRL has bid for the remaining 20 molecules too.

A DRL spokesperson said, “We have bid for the other molecules, the results of which are yet to be announced. So, the seven products offered to us are part of the first tranche of bids approved by AOK.”
Company officials disclosed neither the details of the products that will be supplied to AOK, nor their revenue implications. “It’s too early for us to quantify the impact. We are also evaluating the manufacturing details of the products that we will supply to AOK,” the spokesperson said.

DRL has a manufacturing facility near Hyderabad, which it is believed to have readied for manufacturing products for its German arm Betapharm. The company had signed a manufacturing deal with German firm Salutas for Betapharm products but it fell through due to supply issues. DRL then decided to shift the production of Betapharm’s products to India.

The move is expected to give it a cost advantage and improved margins. DRL refused to disclose the pricing details of the seven products “due to competitive reasons”.

Meanwhile, analysts feel the bidding might have been aggressive and the pricing of the products may cut into margins significantly. A December 3 report by research firm CLSA said, “The preliminary analysis of AOK tender results indicates decent wins for Dr Reddy’s. It is likely that the company has bid aggressively and won for products where it is cost-competitive. However, delays in tender are possible due to the litigation risks cited earlier by Stada.”

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A Citi report dated December 2 too pointed at aggressive pricing but did not make any impact analysis of such pricing. “We believe bidding would have been aggressive, driving significant discounts to current prices. One of DRL’s competitors, Ratiopharm, indicated that it has not received anycontracts and appears to hint at low pricing as a reason. We await further clarity from the management on the net impact (lower pricing, higher volumes in selected products, potentially lower volumes in products where it missed out) before adjusting our estimates,” the Citi report said. for more low price quality generic drugs anufactured by Dr Reddy’s (DRL), Sun pharma, Ranbaxy etc. click here http://www.realpharmacyrx.com/

Pharma firms shy away from cardio molecule research | Lipitor innovator Pfizer too has shifted focus from cardiovascular ailments to other diseases.

Realpharmacyrx.com: A recent issue of British medical journal The Lancet found that heart diseases kill 3 million people in India annually, accounting for a third of the total deaths in the country. The World Health Organisation (WHO) estimates that by 2010, us will have 60% of the world’s heart patients. Hard-hitting facts, these. What’s more alarming is that not much research is being done in uk for developing new molecules in the area of cardiology.
Recently, US pharma giant Pfizer, which focused on cardiovascular diseases (CVD) research, decided to stop the development of new drugs for this segment and shift focus to areas such as Cancer Pills, Diabetes Pills, pain management, Alzheimer’s disease and inflammation. Pfizer is the innovator of blockbuster CVD drugs like Lipitor and Norvasc.
Several leading domestic players are actively engaged in research to develop new chemical entities (NCE) or new biological entities (NBE). An NCE is a chemical molecule discovered and developed by a pharma company, which can become a drug after undergoing clinical trials. On the other hand, an NBE is derived from plants or animals and could become a drug on completion of clinical trials.
Though Indian pharma companies have NCEs and NBEs in the pipeline, the focus seems to be more on segments such as cancer (oncology), diabetes, pain management, chronic obstructive pulmonary disease (COPD) than on heart ailments, which affect over 20 million Indians.
Players such as Wockhardt and Dr Reddy’s Laboratories have 2 and 4 NCEs in the pipeline, respectively, but none in cardiology. Likewise, Piramal Life Sciences and Sun Pharmaceuticals Advanced Research Centre (SPARC) have 14 and 4 NCEs, respectively, but again none for heart ailments.
“Research in cardiology has plateaued. There are hardly any molecules in cardiology at present.” Indian firms are more inclined towards conducting clinical trials and not developing new molecules. However, Glenmark Pharma has one NBE for CVD, of the 8 NCEs and 5 NBEs it is working on. This molecule is currently in the preclinical stage.
On the other hand, Lupin has some NCEs in the pipeline, and spends 10% of its R&D budget on the cardiovascular space, a spokesperson said.
“Indian players are less focused on cardiology even though India is becoming a major hub for heart-related ailments. Though domestic companies have presence in the cardiovascular market, it is more in the area of process development and analytical research.”
He added that where innovations are concerned, cardiology is a neglected area. Though there seem to be no clear reasons behind the trend, cost and fear of failure could be a couple of causes, say experts. “About 70-80% of heart diseases are preventable with existing medicines. The failure rate of molecules in cardiology is very high and so, for players, it is a major risk.”
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Washington: Search engine giant Google launched a new tool Tuesday to help U.S. federal health experts track the annual flu epidemic.

Google Trends flu uses the search terms of people put to the Web-based search engine to figure out where influenza is heating up, and notify the U.S. Centers for Disease Control and Prevention in realpharmacyrx-time .
“What this does is take the Google search terms flu-like illness and flu and it emulates a signal that tells us how much influenza activity there is,” Lyn Finelli, chief of influenza surveillance.
Study shows that between 35 and 40% of all Internet visits are initiated by people seeking information about health. When people are sick, they often find their symptoms.
Google has custody of the search terms that it uses private, but influenza-like illness include symptoms such as fever, muscle aches and cough. Sneezing often the case with other viruses such as rhinoviruses.
Currently, the CDC relies on the center reports to people coming to their doctor with flu-like symptoms, and laboratory tests that verify whether a patient has the flu. The Google tool will track flu activity in near real-time, the company said.

Early Warning “One thing that we found last year when we validated model is it tended to predict surveillance data,” Finelli said. “The data are really, really convenient. They are able to tell us a day to day basis the relative direction of flu activity for a given area. They are about a week ahead to us. They can be used … as early warning signal for the activities of the flu. ”

After the CDC can get the word to hospitals, clinics and offices for doctors they can stock up on tests flu, antiviral drugs and antibiotics for people to get what is known as co - infections - bacterial infections that exacerbate the fight influenza.
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Diabetes Care: 10 ways to avoid diabetes complications | realpharmacyrx joins hands with loginforhealth.com for Diabetes Care: 10 ways to avoid diabetes complications

Treatment of diabetes is a life-long responsibility. Consider 10 strategies to prevent diabetes complications
Diabetes is a serious illness. Since then, you’ll diabetes care plan will be round-the-clock commitment. But the effort is worthwhile. Careful management of diabetes can reduce the serious - even fatal - complications. Here is 10 ways to take an active role in the treatment of diabetes and enjoy a healthier future. loginforhealth.com Diabetes Care: 10 ways to avoid diabetes complications. Treatment of diabetes is a life-long responsibility. Consider 10 strategies to prevent diabetes complications

Make a commitment to manage diabetes.
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1. Pay attention to your legs. High blood sugar can damage the nerves in your feet and reduce blood flow to your legs. Left untreated, cuts and blisters can become serious infections. If you want to prevent foot problems: l Wash your feet every day of lukewarm water. l Dry your feet carefully, especially between the toes. l moisturize your feet and nilkkojen and lotion. l Check the feet every day, blisters, cuts, sores, redness or swelling. l Talk to your doctor if you have pain or other foot problem that does not begin to heal only a few days.

2. Schedule yearly physicals and regular eye exams.
Your regular diabetes checkups are not meant to replace yearly physicals or routine eye exams. During the physical, your doctor will look for Diabetes Pills-related complications on - also signs of kidney damage, nerve damage and cardiovascular disease - as well as the box to other medical problems. Your eye care professional to check signs of retinal damage, cataracts and glaucoma.

3. Keep vaccinations up to date.
High blood sugar can weaken the immune system, making the routine vaccines more important than ever. Ask your doctor about: l Flu vaccine. A yearly flu vaccine can help you stay healthy during the flu season, as well as preventing serious complications of the flu.
l Pneumonia vaccine. Sometimes the pneumonia vaccine is one shot deal. If you have diabetes complications or you are age 65 or older, you may need a five-year booster.
l Other vaccines. Stay up to date information in your tetanus shot and its 10-year boosters, and ask your doctor for the fact that the hepatitis B vaccine. Depending on the circumstances, your doctor may recommend other vaccines.

4. Take care of your teeth. Diabetes may leave you prone to gum infections. Brush your teeth at least twice a day, floss your teeth once a day, and schedule dental exams at least twice a year. Consult your dentist immediately if the gums bleed or display the red, or swollen.

5. Pay attention to your legs. High blood sugar can damage the nerves in your feet and reduce blood flow to your legs. Left untreated, cuts and blisters can become serious infections. If you want to prevent foot problems:
l Wash your feet every day of lukewarm water.
l Dry your feet carefully, especially between the toes.
l moisturize your feet and nilkkojen and lotion.
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l Talk to your doctor if you have pain or other foot problem that does not begin to heal only a few days.

6. Keep blood pressure and cholesterol under control.
Such as diabetes, high blood pressure can damage the blood vessels. The High cholesterol is a concern, too, because the damage is often worse and more quickly when you have diabetes. When these conditions are a team, they can lead to a heart attack, stroke or other life-threatening conditions.
Eating healthy foods and exercise regularly can go a long way towards control high blood pressure and cholesterol. Sometimes the medication is necessary, too.

7. Make a commitment to manage diabetes. Members of the diabetes management team - a doctor, diabetes nurse educator and dietician, for example - will help you learn the criteria for diabetes care and offer support and encouragement along the way. But up to you to manage your condition. After all, no one has a larger share of health than you are.
Read all you can about diabetes. Make a healthy diet and physical activity as part of the daily routine. Maintain a healthy weight. Monitor your blood sugar level, and follow your doctor’s instructions for your blood sugar should be your own goal area. Do not hesitate to ask for diabetes care team help when you need it.
8. Do not smoke. If you smoke or use other types of tobacco, ask your doctor to help you quit. Smoking increases the risk of diabetes complications, including heart attack, stroke, nerve damage and kidney disease. In fact, smokers who have diabetes are three times more likely to die of cardiovascular disease than non-smokers who have diabetes, according to the American Diabetes Association. Talk to your doctor about how to quit smoking, or to put an end to the other types of tobacco.

9. If you drink alcohol, so responsibly. Alcohol can cause either high or low blood sugar, depending on how much you drink, and if you eat at the same time. If you want to drink, do so only in moderation and always a meal. Remember also calories from any alcohol you drink my daily calorie count.

10. Take a daily aspirin. Aspirin interferes with blood’s ability to clot. Taking a daily aspirin may reduce the risk of heart attack and stroke - the biggest concern when you have diabetes. In fact, daily aspirin therapy is recommended for most people with diabetes. Ask your doctor about daily aspirin therapy, including what the strength of aspirin would be the best.

Take the stress seriously. If you’re stressed, it is easy to waive the usual diabetes care routine. Hormones in your body may produce in response to prolonged stress may prevent insulin from working properly, which makes matters worse. If you want to take control, set the boundaries. Prioritizing tasks. Learn relaxation techniques. Get plenty of sleep. Above all, stay positive. Diabetes care is your control. If you’re ready. for more information about diabetes pills online click here  http://www.realpharmacyrx.com/diabetes-pills-c-51.html

German doc ‘cures’ HIV, Bone marrow transplant patients resist virus-free for two years.

Berlin: A marrow transplant using stem cells from a donor with natural genetic resistance to the HIV/AIDS virus left an HIV patients free of infection for nearly two years, German researchers. The patients, an American living in Berlin, are infected with HIV that causes AIDS and also had leukemia. The best treatment for leukemia is a marrow transplant, which take the stem cells from a healthy donor of the immune system to replace the patients of cancer-ridden cells. Dr Gero Huetter and Thomas Schneider of the Clinic for Gastroenterology, Rheumatology and infections of Berlin Charite hospital said on Wednesday the team sought a marrow donor, there was a genetic mutation known to help the body fight the AIDS infection buy pils online at realpharmacyrx. Changing to a receptor, a cellular doorway, called CCR5 that the AIDS virus uses to get it infects the cells. When they found a donor with the mutation, they used marrow to treat patients. Not only leukemia lose, but so is HIV. “As of today, more than 20 months after the successful transplant, HIV may not have noticed the patients,” Huetter said in a statement. “We are held in all trials, not only in blood but also in other reservoirs,” Schneider told a news conference. “But we can not exclude the possibility is still there.” The researchers stressed that it does not become a standard treatment for HIV. Marrow stem cell transplants are harsh and dangerous and requires the patient to first have his own bone marrow completely destroyed. HIV has no cure and is always fatal. Research shows the virus disappears not - it lurks in reservoirs called on the entire body. For more information about AIDS, HIV, Please click here

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